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Medical Literature for

Health Benefits of Elevated Serum Albumin

All-cause mortality
Albumin and all-cause mortality risk in insurance applicants
Conclusion: When stratified by age and sex, albumin discriminated between all-cause mortality risks in healthy adults at all ages.

 

Albumin concentrations control cancer
Albumin concentration controls cancer
Conclusion: High albumin levels throughout life bring security against all forms of cancer.

 

Antiretroviral therapy
Association of serum albumin concentration with mortality, morbidity, CD4 T-cell reconstitution among Tanzanians initiating antiretroviral therpapy
Conclusion:  Serum albumin concentrations identify adults at high risk for mortality.

 

Breast cancer
Is serum albumin an independent predictor of survival in patients with breast cancer
Conclusion:  Low levels of serum albumin adversely affected survival by a statistically significant level for all stages of breast cancer.

 

Carcinomas
Low serum albumin levels and liver metastasis are powerful prognostic markers for survival in patients with carcinomas of unknown primary site
Conclusion: Lymphopenia and low serum albumin levels were identified as two new independent markers of prognosis in patients with carcinomas of unknown primary site.

 

Cardiovascular disease and HIV
Serum albumin and short-term risk for mortality and cardiovascular disease among HIV-infected veterans
Conclusion: Low serum albumin levels are strongly predictive of mortality risk.

 

Cirrhosis
Albumin: Pathophysiologic basis of its role in the treatment of cirrhosis and its complications.
Conclusion: Albumin function is reduced in liver failure. Albumin infusion reduces mortality.

 

Cognitive impairment
Serum albumin concentration and cognitive impairment
Conclusion: Low serum albumin is independently associated with increased odds of cognitive impairment in the elderly population.

 

Colorectal cancer
Serum albumin: a prognostic indicator in patients with colorectal cancer
Conclusion: Pre-treatment serum albumin concentration was found to be an independent prognostic indicator in colorectal cancer.

 

Coronary disease and myocardial infarction
Serum albumin and risk of myocardial infarction and all-cause mortality in the Framingham Offspring Study
Conclusion: Low serum albumin concentrations appear to be associated with an increased risk of coronary disease in both men and women.

 

Coronary intervention
The prognostic value of serum albumin levels on admission in patients with acute ST-segment elevation myocardial infarction undergoing a primary percutaneous coronary intervention
Conclusion: Low serum albumin is a strong predictor for mortality.

 

Gastric carcinoma
Serum albumin as a significant prognostic factor for patients with gastric carcinoma
Conclusion: Pretherapeutic serum albumin level is a significant prognostic factor for patients with gastric carcinoma.

 

Head and neck cancer and cirrhosis
The roles of albumin levels in head and neck cancer patients with liver cirrhosis undergoing tumor ablation and microsurgical free tissue transfer
Conclusion: Low serum albumin was associated with medical complications.

 

Heart failure
Serum albumin concentration and heart failure risk The Health, Aging, and Body Composition Study
Conclusion: Low serum albumin levels are associated with increased risk for heart failure in the elderly in a time dependent manner independent of inflammation and incident coronary events.

 

Ischaemic stroke
Serum albumin in ischemic stroke patients: the higher the better. The Bergen Stroke Study
Conclusion: High serum albumin is associated with better outcome and lower mortality in ischaemic stroke patients.  High serum albumin may be neuroprotective in ischaemic stroke in humans.

 

Liver transplant
Revision of MELD to include serum albumin improves prediction of mortality on the liver transplant waiting list
Conclusion: A linear, inverse relationship was observed between albumin and 3-month mortality.

 

Mortality from diseases
Association between serum albumin and mortality from cardiovascular disease, cancer, and other causes
Conclusion: There was a marked increase in mortality rate with decreasing serum albumin concentrations.

 

Mortality in older persons
Serum albumin level and physical disability as predictors of mortality in older persons
Conclusion: Serum albumin level is an independent risk factor for all-cause mortality in older persons.

 

Mortality risk
Association of serum albumin and mortality risk
Conclusion: Serum albumin concentration is an independent predictor of mortality risk.  A direct protective effect of the albumin molecule is suggested by the persistence of the association after adjustment for other known risk factors.

 

Ovarian cancer
Preoperative serum albumin is an independent prognostic predictor of survival in ovarian cancer
Conclusion: Low levels of serum albumin adversely affected survival by a statistically significant level across all stages of ovarian cancer.

 

Postoperative complications
Preoperative serum albumin but not prealbumin is an excellent predictor of postoperative complications and mortality in patients with gastrointestinal cancer
Conclusion: Albumin level has superior predictive value.

 

Prostate cancer and other cancers
The relationship between the presence and site of cancer, an inflammation based prognostic score and biochemical parameters.  Intial results of the Glasgow Inflammation Outcome Study
Conclusion: The systemic inflammatory response is common in a large patient cohort, increased by the presence of cancer and associated with high C-reactive protein and low serum albumin levels.

 

Serum albumin and cancer survival
Pretreatment serum albumin as a predictor of cancer survival:  a systematic review of the epidemiological literature
Conclusion: Higher serum albumin was correlated with better survival in the majority of studies.  These studies included gastrointestinal cancer, lung cancer and other cancers.

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